Low Dose Naltrexone (LDN) Custom-Compounded Rx

 Low Dose Naltrexone (LDN) is a compounded version of the prescription drug naltrexone, made at much lower doses (0.5–4.5 mg). While high-dose naltrexone is FDA-approved for addiction, LDN is used off-label to help modulate the immune system and reduce inflammation. Patients and providers are turning to LDN for conditions ranging from autoimmune disease to chronic pain. 

LDN temporarily blocks opioid receptors, prompting the body to increase production of endorphins—your natural pain and immune regulators. The result is improved immune function, reduced inflammation, and symptom relief for a range of chronic conditions.

• Enhances natural endorphin production
• Balances immune system response
• Reduces pro-inflammatory cytokines
• Supports the body’s own healing mechanisms

Though not FDA-approved for these uses, LDN is being used to support treatment for: 

• Hashimoto’s Thyroiditis
• Rheumatoid Arthritis
• Multiple Sclerosis
• Fibromyalgia
• Lupus
• Psoriasis
• Chronic Fatigue Syndrome
• Interstitial Cystitis
• CRPS
• Crohn’s Disease
• Ulcerative Colitis
• Endometriosis
• Long COVID Symptoms
• Migraines
• Cancer

• Start low, go slow: Initial dose often 0.5–1 mg, titrated up
• Improvements may take weeks or months
• Works best with long-term use
• Dosing is personalized for each patient
• Close monitoring recommended for thyroid or autoimmune conditions

 Side effects from Low Dose Naltrexone (LDN) are generally mild and uncommon, especially compared to traditional immunosuppressants or pain medications.  

• Vivid dreams / sleep disturbances: ~10–20%
  Often occurs in the first 1–2 weeks and usually resolves with time or dose adjustments.
• Headache: ~5–10%
  Typically mild and transient.
• Nausea: ~5–10%
  More common if starting at a higher dose or without food. 
• Anxiety / mood changes: <5%
  Rare, but can occur—especially if titration is too rapid.
• Worsening of autoimmune symptoms (temporary flare): <5%
  Some people with autoimmune conditions experience a brief flare before seeing improvements.

Serious side effects are very rare.

LDN is considered extremely safe at low doses (0.5–4.5 mg). It is not known to cause organ damage, dependence, or significant long-term effects in clinical use.

Avoid if taking:
• Opioids (oxycodone, morphine, hydrocodone)
• Codeine-containing cough medications
 

Use caution with:
• Immunosuppressants

Low Dose Naltrexone isn’t available in standard pharmacies. It must be compounded for each patient. 

At Gold Country Compounding, we offer:
• Custom strengths: 0.1 mg to 4.5 mg (or higher)
• Capsules, oral liquids, or sublingual drops and troches
• Dye-free, gluten-free, preservative-free options
• Fast turnaround and expert pharmacist support
• Shipping available within California

1. Talk to your provider about whether LDN is right for you
2. Have your provider send your prescription to us
3. We’ll compound your LDN and follow up if titration is needed
 

Need a provider? We can refer you to one familiar with LDN therapy.